PRF-From self to self

PRF, which belongs to a new second generation of platelet concentrates, with simplified processing, and not requiring biochemical blood handling, has several advantages over traditionally prepared PRP, which has been widely used for accelerating soft tissue and hard tissue healing. However, the preparation being strictly autologous, the amount of PRF obtained is limited. Choukroun’s platelet-Rich Fibrin (PRF) incorporates leucocytes, platelets and a wide range of healing proteins within a dense fibrin matrix. It has a strong fibrin architecture and slow releasing growth factors and glycoproteins over several days. It is a natural bioactive membrane, which can enhance soft/hard tissue healing, at the same time, can also protect surgical sites,grafted materials from external aggressions. This article describes the evolution of this second generation platelet concentrate and its multipleuses in various surgical procedures.we have attempted to give an overview of PRF including its uses, advantages, its preparation & its microscopic structures.